XIV ̳ - ADVANCED TECHNOLOGIES OF SCIENCE AND EDUCATION

English





... .. ˲ί ֲ ί ˲ί Ҳ ֲ ST.

:

..,

  ˲ί ֲ ʠ ί ˲ί Ҳ Ӡ ՠ ɠ ɠ ̠ Ǡ ֲ ST

: , , ST.

, () - [6]. () : , , () [7, 8, 9, 10, 12, 13, 14]. Ѡ , , , [2].

() , 50 - 70% , [1, 4, 11]. . . . ' . ³ ' .

, , .

ST.

200 ST, 고 1 2004 - 2006 . 24 . 120 (60%) 80 (40%) 38 76 ( 56,5 8,6 ).

ij ST , , (1999) [2], 䳺 ST 㳿 (1999) [5] (2002) [3].

ST ó, - V NYHA, , 糿 (), , , , , , 㳿 , , .

ij --" ST 148 (74%) . 䳿: , 䳿 . ( 0,1 /) ST - . ij --" ST 52 (26%) , , 0,1 /.

T.Killip, J..Kimball (1967) [11]: - 124 (62%) ( 1- ), - 46 (23%) ( 2- ) , - 30 (15%) ( 3- ).

ij 150 (75%) : 䳿 - 54 (27%), 䳿 - 86 (43%) 10 (5%) .

30 - III ( i ). , , , , 䳺 .

() 12 6- NEC-6. () Sonos 100 (Hewlett Packard", USA) . г ' Cardiac Reader" (Roche Diagnostics Corporation, Indianapolis, USA). г - (-) (-", ). 24 EC-GO" (Meditech", ) Cardio Tens" (Meditech", ). ʳ : -1 (-1), - (-), 2 (2), 3'-5'- (), (6- 1α) .

" SD". t . Excel 2000. <0,05.

().

ST

(Mm)
ST, (n=200)

(n=30)

(n=124)

(n=46)

(n=30)

-1, / 18,551,05*□∆ 22,611,57*○∆ 26,221,88*○□ 8,460,54
-, / 25,771,25*□∆ 38,781,58*○∆ 50,791,85*○□ 13,551,05
2, / 168,888,25*□∆ 185,558,79*○∆ 203,8911,12*○□ 141,345,54
, / 5,950,14*□∆ 5,050,11*○∆ 4,170,08*○□ 7,950,21
6-1α, / 76,152,85*□∆ 68,452,75*○∆ 60,112,67*○□ 93,553,05
, % 54,53,45*□∆ 44,212,88*○∆ 35,912,68*○□ 58,685,85

: г : * - ; ○ - 1 ; □ - 2 ; ∆ - 3 (<0,05-0,00001).

(1, 2 3) ST : -1 - 2,19 (p<0,0001), 2,67 (p<0,0001) 3,19 (p<0,00001), - - 47,4% (p<0,001), 65,1% (p<0,0001) 73,3% (p<0,0001) 2 - 16,3% (p<0,05), 23,8% (p<0,01) 30,7% (p<0,01), . ST , 3 , - 1 .

(1, 2 3) ST : 6- 1α - 19,6% (p<0,05), 26,8% (p<0,01) 35,7% (p<0,01) - 25,2% (p<0,01), 36,5% (p<0,01) 47,6% (p<0,001), . ST , 1 , - 3 .

, ' : -1, - 2 , , 6- 1α ST.

' . ' -1 (r=-0,68, p<0,01), - (r=-0,66, p<0,01) 2 (r=-0,64, p<0,01) . ' -1 (r=0,72, p<0,01), - (r=0,70, p<0,01) 2 (r=0,68, p<0,01) . ' -1 (r=0,68, p<0,01), - (r=0,66, p<0,01) 2 (r=0,64, p<0,01) - .

' (r=0,68, p<0,01) 6- 1α (r=0,66, p<0,01) . ' (r=-0,69, p<0,01) 6- 1α (r=-0,67, p<0,01) . ' (r=-0,66, p<0,01) 6- 1α (r=-0,64, p<0,01) - .

ST. , , - [6, 7, 8, 9], .

1. ST -1, - 2, 6- 1α .2. -1, - 2 ' : ST.

3. 6- 1α ' : ST.

4. ST .

˳:

1. .., .. // . - 2004. - 9 (015). - . 18 - 24.

2. - // . . . - 2001. - 2. - . 48 - 51.

3.Bertrand M.E., Simoons M.L., Fox K.A.A., Wallentin L.C., Hamm C.W., McFadden E., De Feyter P.J., Specchia G., Ruzyllo W. Management of Acute Coronary Syndromes in patients presenting without persistent ST-segment elevation. Task Force of the ESC // Eur. Heart J. - 2002. - Vol. 23. - P. 1809 - 1840.

4.Boden W.E., Roberts R. Prognosis and management of patients with non-Q-wave myocardial infarction. In: Zipes D. ed. Phyladelphia: Lea and Febiger, 1991. - P. 143 - 160.

5.Braunwald E., Antman E.M., Beasley J.W., Califf R.M., Cheitlin M.D., Hochman J.S., Jones R.H., Kereiakes D., Kupersmith J., Levin T.N., Pepine C.J., Schaeffer J.W., Smith E.E. III, Steward D.E., Theroux P. ACC / AHA guidelines for the management of patients with unstable angina and non-ST-elevation myocardial infarction: executive summary and recommendations: report of the American College of Cardiology / American Heart Association Task Force on Practice Guidelines (Committee on Management of Patients with Unstable Angina ) // Curculation. - 2000. - Vol. 102. - P. 1193 - 1209.

6.Cai H., Harrison D.G. Endothelial Dysfunction in Cardiovascular Diseases: The Role of Oxidant Stress // Circ. Res. - 2000. - Vol. 87. - P. 840.

7.Egashira K. Clinical importance of endothelial function in arteriosclerosis and ischemic heart disease // Circ. J. - 2002. - Vol. 66. - P. 529 - 533.

8.Endemann D.H., Schiffrin E.L. Endothelial function // J. Am. Soc. Nephrol. - 2004. - Vol. 15. - P. 1983 - 1992.

9.Grossman J.D., Morgan J.P. Cardiovascular effects of endothelin // News Physiol. Sci. - 1997. - Vol. 12. - P. 113 - 117.

10.Iwanaga Y., Kihara Y., Inagaki K. et al. Differential effects of angiotensin II versus endothelin-1 inhibitions in hypertrophic left ventricular myocardium during transition to heart failure // Curculation. - 2001. - Vol. 31. - 104 (5). - P. 606 - 612.

11.Killip T., Kimball J.T. Treatment of myocardial infarction in a coronary care unit: a two year experience with 250 patients // Am. J. Cardiol. - 1967. - Vol. 20. - P. 457 - 464.

12.Kinlay S., Behrendt D., Wainstein M. et al. Role of Endothelin-1 in the Active Constriction of Human Atherosclerotic Coronary Arteries // Curculation. - 2001. - Vol. 104. - P. 1114.

13.Perticone F., Ceravolo R., Pujia A. et al. Prognostic Significance of Endothelial Dysfunction in Hypertensive Patients // Curculation. - 2001. - Vol. 104. - P. 191.

14.Vita J.A., Keaney J.F.Jr. Endothelial function: a barometer for cardiovascular risk? // Circulation. - 2002. - Vol. 106 (6). - P. 640 - 642.

.

A ɠ Ƞ Ӡ ՠ Ѡ ̠ ̠ ̠ Ǡ Ƞ ST ..

200 I - III ( T.Killip, J..Kimball), ST ( 56,5 8,6 ) 30 II - .

. ST.

: , , ST.

Summary.

THE INFLUENCE OF ENDOTHELIAL DYSFUNCTION ON DEVELOPMENT OF ACUTE LEFT VENTRICULAR FAILURE IN PATIENTS WITH ACUTE CORONARY SYNDROME WITHOUT ST-SEGMENT ELEVATION

Prikhoda I.V.

200 patients with acute left ventricular failure (T.Killip, J..Kimball I - III class) developed as a result of acute coronary syndrome without ST-segment elevation (mean age 56,58,6 years) and 30 patients with stable angina pectoris II - functional class have been examined.

The interrelation of class acute left ventricular failure and intensity of the activation of biological markers of endothelial dysfunction. The received results expand the conception on the importance endothelial dysfunction of in acute left ventricular failure pathogenesis in patients with acute coronary syndrome without ST-segment elevation.

Key words: endothelial dysfunction, acute left ventricular failure, acute coronary syndrome without ST-segment elevation.


!

:
<a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <code> <em> <i> <strike> <strong>